Tandem sp3 C-H functionlization/decarboxylation of 2-alkylazaarenes with coumarin-3-carboxylic acids

Org Lett. 2014 Feb 7;16(3):796-9. doi: 10.1021/ol403541g. Epub 2014 Jan 17.

Abstract

The catalyst-free sp(3) C-H functionalization of 2-alkylazaarenes has been achieved in the reaction with (thio)coumarin-3-carboxylic acids. Followed by a tandem decarboxylation, this method provides facile synthesis of biologically important azaarene-substituted 3,4-dihydro(thio)coumarins in a single step in high yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemistry*
  • Catalysis
  • Coumarins / chemistry*
  • Decarboxylation
  • Molecular Structure
  • Sulfhydryl Compounds / chemistry*

Substances

  • Aza Compounds
  • Coumarins
  • Sulfhydryl Compounds
  • coumarin-3-carboxylic acid