Palladium-catalyzed oxidative olefination of phenols bearing removable directing groups under molecular oxygen

J Org Chem. 2014 Feb 7;79(3):1521-6. doi: 10.1021/jo4027403. Epub 2014 Jan 24.

Abstract

An efficient Pd(II)-catalyzed oxidative olefination of phenols bearing removable directing groups with molecular oxygen as the sole oxidant has been developed. This reaction protocol provides an efficient and robust synthetic tool for the synthesis of o-alkenyl phenols under mild conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry*
  • Catalysis
  • Oxidation-Reduction
  • Oxygen / chemistry*
  • Palladium / chemistry*
  • Phenols / chemistry*

Substances

  • Alkenes
  • Phenols
  • Palladium
  • Oxygen