Abstract
A series of novel 1,2,4-triazolo [3,4-a] phthalazine derivatives were synthesized in five steps from a common precursor, phthalic anhydride. Most of synthesized phthalazine derivatives showed inhibitory activity against Staphylococcus aureus. One of phthalazine derivatives 5l showed inhibitory activity against all tested bacterial and fungal strains.
Keywords:
Antimicrobial; Phthalazine; Synthesis; Triazole.
Copyright © 2014. Published by Elsevier Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Dose-Response Relationship, Drug
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Microbial Sensitivity Tests
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Molecular Structure
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Phthalazines / chemical synthesis
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Phthalazines / chemistry
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Phthalazines / pharmacology*
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Staphylococcus aureus / drug effects*
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Structure-Activity Relationship
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / pharmacology*
Substances
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1,2,4-triazolo(3,4-a)phthalazine
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Anti-Bacterial Agents
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Phthalazines
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Triazoles