Copper-promoted oxidative coupling of enamides and alkynes for the synthesis of substituted pyrroles

Chemistry. 2014 Feb 10;20(7):1839-42. doi: 10.1002/chem.201304565. Epub 2014 Jan 22.

Abstract

An efficient copper-promoted oxidative coupling of enamides with alkynes has been developed for the synthesis of substituted pyrroles. The reaction proceeded through C-H and N-H bond functionalization of enamides under mild conditions.

Keywords: alkynes; copper; enamides; methodology; pyrroles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Amides / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Oxidative Coupling
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry

Substances

  • Alkynes
  • Amides
  • Pyrroles
  • Copper