Abstract
A novel series of N-methyl-bisindolylmaleimides were synthesized and evaluated for their inhibitory activities against nine tumor cell lines. Some of the compounds showed an interesting activity against the tested cell lines. The most potent compounds 5e and 5j displayed antiproliferative activity with 50% inhibitory concentration values in the μM range against some tested cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / pharmacology*
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Inhibitory Concentration 50
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KB Cells
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MCF-7 Cells
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Maleimides / chemical synthesis*
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Maleimides / chemistry
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Maleimides / pharmacology*
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Molecular Structure
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Structure-Activity Relationship
Substances
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1H-indole-2-carboxylic acid (2-(3-(4-(1H-indol-3-yl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-ethyl)-amide
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Antineoplastic Agents
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Indoles
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Maleimides
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pyridine-2-carboxylic acid (2-(3-(4-(1H-indol-3-yl)-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-ethyl)-amide
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bisindolylmaleimide