Abstract
Polymorphonuclear cells diapedesis has an important contribution to the induced Mannhemia haemolytica (M. haemolytica) infection lung inflammation and IL-8 is the primary polymorphonuclear chemoattractant. Using a bovine IL-8/luciferase transiently transgenized mouse model, the orchestration among M. haemolytica, IL-8 promoter activation and neutrophilia was followed in real time by in vivo image analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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Disease Models, Animal*
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Female
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Interleukin-8 / metabolism*
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Luciferases / metabolism
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Luminescent Agents / metabolism
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Lung / immunology
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Lung / microbiology
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Mannheimia haemolytica / immunology*
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Mice
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Mice, Inbred Strains
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Mice, Transgenic
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Neutrophils / immunology*
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Neutrophils / microbiology
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Pasteurella Infections / immunology*
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Pneumonia, Bacterial / immunology*
Substances
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Interleukin-8
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Luminescent Agents
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Luciferases