Abstract
Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti-tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / metabolism
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Humans
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Macrolides / chemical synthesis
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Macrolides / isolation & purification
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Macrolides / metabolism
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Macrolides / pharmacology*
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Molecular Structure
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Resorcinols / chemical synthesis
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Resorcinols / isolation & purification
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Resorcinols / metabolism
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Resorcinols / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Macrolides
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Resorcinols