A graphene oxide and exonuclease-aided amplification immuno-sensor for antigen detection

Chem Commun (Camb). 2014 Mar 11;50(20):2679-81. doi: 10.1039/c4cc00128a.

Abstract

We have developed a novel immuno-sensor applied to protein detection based on exonuclease III (Exo III)-induced signal amplification, multiplex binding of the biotin-streptavidin system and the fluorescence quenching ability of graphene oxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens / analysis*
  • Biological Assay*
  • Exodeoxyribonucleases / chemistry*
  • Graphite / chemistry*
  • Limit of Detection
  • Oxides / chemistry*
  • alpha-Fetoproteins / chemistry

Substances

  • Antigens
  • Oxides
  • alpha-Fetoproteins
  • Graphite
  • Exodeoxyribonucleases
  • exodeoxyribonuclease III