Latent classiness and other mixtures

Behav Genet. 2014 May;44(3):205-11. doi: 10.1007/s10519-013-9637-3. Epub 2014 Jan 30.

Abstract

The aim of this article is to laud Lindon Eaves' role in the development of mixture modeling in genetic studies. The specification of models for mixture distributions was very much in its infancy when Professor Eaves implemented it in his own FORTRAN programs, and extended it to data collected from relatives such as twins. It was his collaboration with the author of this article which led to the first implementation of mixture distribution modeling in a general-purpose structural equation modeling program, Mx, resulting in a 1996 article on linkage analysis in Behavior Genetics. Today, the popularity of these methods continues to grow, encompassing methods for genetic association, latent class analysis, growth curve mixture modeling, factor mixture modeling, regime switching, marginal maximum likelihood, genotype by environment interaction, variance component twin modeling in the absence of zygosity information, and many others. This primarily historical article concludes with some consideration of some possible future developments.

Publication types

  • Biography
  • Historical Article
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adolescent Behavior / history
  • Genetic Association Studies / history*
  • Genetics, Behavioral / history*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Models, Genetic*
  • Twin Studies as Topic / history*
  • United States

Personal name as subject

  • Lindon Eaves