Abstract
The phospholipid involvement in the regulation of the functional and structural properties of the nuclear matrix is discussed analysing the results obtained with the enzymic removal of these molecules. Namely phospholipids seem to mediate hydrophobic interactions between nucleic acids and matrix fibrils either directly or indirectly through an association with the non-histone proteins of the matrix.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Fractionation
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Cell Nucleus / analysis
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Cell Nucleus / metabolism*
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Cell Nucleus / ultrastructure
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DNA / metabolism
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Dimethyl Sulfoxide / pharmacology
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Friend murine leukemia virus
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Leukemia, Erythroblastic, Acute / analysis
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Lipids / analysis
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Liver / ultrastructure
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Mice
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Phospholipids / physiology*
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RNA / metabolism
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Rats
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Transcription, Genetic
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Type C Phospholipases / metabolism
Substances
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Lipids
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Phospholipids
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RNA
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DNA
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Type C Phospholipases
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Dimethyl Sulfoxide