Second trimester ultrasound markers of fetal aneuploidy

Clin Obstet Gynecol. 2014 Mar;57(1):159-81. doi: 10.1097/GRF.0000000000000012.

Abstract

Although it is widely accepted that the best time to screen for chromosomal abnormalities is the first trimester, ultrasound evaluation of the fetus in the second trimester has also been shown to be useful for this purpose. A multitude of markers of varying strength has been developed over the past 30 years. In addition, the optimal time to diagnose fetal anomalies with confidence is also the mid second trimester. Therefore, performance of obstetrical ultrasound at this point in gestation continues to be an important component of prenatal care.

Publication types

  • Review

MeSH terms

  • Aneuploidy*
  • Brain Diseases / complications
  • Brain Diseases / diagnostic imaging
  • Choroid Plexus / diagnostic imaging
  • Chromosome Disorders / diagnostic imaging
  • Cysts / complications
  • Cysts / diagnostic imaging
  • Down Syndrome / complications
  • Down Syndrome / diagnostic imaging*
  • Duodenal Obstruction / complications
  • Duodenal Obstruction / diagnostic imaging
  • Facial Bones / diagnostic imaging*
  • Female
  • Fetal Heart / diagnostic imaging
  • Head and Neck Neoplasms / complications
  • Head and Neck Neoplasms / diagnostic imaging
  • Heart Defects, Congenital / complications
  • Heart Defects, Congenital / diagnostic imaging
  • Hernia, Umbilical / complications
  • Hernia, Umbilical / diagnostic imaging
  • Holoprosencephaly / complications
  • Holoprosencephaly / diagnostic imaging
  • Humans
  • Hydrocephalus / complications
  • Hydrocephalus / diagnostic imaging
  • Intestinal Atresia
  • Likelihood Functions
  • Lymphangioma, Cystic / complications
  • Lymphangioma, Cystic / diagnostic imaging
  • Nasal Bone / diagnostic imaging
  • Nuchal Translucency Measurement / methods*
  • Pregnancy
  • Pregnancy Trimester, Second*
  • Pyelectasis / diagnostic imaging
  • Subclavian Artery / abnormalities
  • Subclavian Artery / diagnostic imaging
  • Ultrasonography, Prenatal / methods
  • Umbilical Cord / diagnostic imaging

Supplementary concepts

  • Familial duodenal atresia