Topical application of clobetasol-17-propionate inhibits the intra-epidermal accumulation of polymorphonuclear leukocytes

Acta Derm Venereol. 1988;68(1):57-60.

Abstract

The in vivo effect of topical clobetasol-17-propionate (CP) on the leukotriene B4- and trauma-induced intra-epidermal accumulation of polymorphonuclear leukocytes (PMN) was investigated in normal volunteers. PMN accumulation was assessed using elastase, a specific and sensitive marker for these cells. A profound inhibition of PMN accumulation was shown in the first 2 days of treatment with CP, an effect that faded away after a treatment of 2 weeks.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Betamethasone / analogs & derivatives*
  • Clobetasol / administration & dosage
  • Clobetasol / analogs & derivatives*
  • Female
  • Humans
  • Leukocyte Count
  • Leukotriene B4 / analysis
  • Male
  • Neutrophils / drug effects*
  • Skin / injuries
  • Skin / pathology*

Substances

  • Leukotriene B4
  • Betamethasone
  • Clobetasol