Abstract
Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S)-4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.0(1,5)]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Lipopolysaccharides / pharmacology
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Stereoisomerism
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Streptomyces / chemistry*
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / drug effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lipopolysaccharides
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Sesquiterpenes
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Tumor Necrosis Factor-alpha
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strepsesquitriol
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Nitric Oxide