Response to "can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?": evaluation of CYP3A activity with microdoses of midazolam

Clin Pharmacol Ther. 2014 May;95(5):490-1. doi: 10.1038/clpt.2014.28. Epub 2014 Feb 6.

Authors

N Hohmann¹, B Halama¹, N Siller¹, G Mikus¹, W E Haefeli¹

Affiliation

¹ Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

PMID: 24503628
DOI: 10.1038/clpt.2014.28

No abstract available

Publication types

Letter
Comment

MeSH terms

Cytochrome P-450 CYP3A / genetics*
Cytochrome P-450 CYP3A / metabolism*
Female
Humans
Ketoconazole / pharmacology*
Male
Midazolam / administration & dosage*
Midazolam / pharmacology*

Substances

Cytochrome P-450 CYP3A
Midazolam
Ketoconazole