Association of IL-17F gene polymorphisms with renal transplantation outcome

Transplant Proc. 2014 Jan-Feb;46(1):121-3. doi: 10.1016/j.transproceed.2013.05.015.

Abstract

Objective: Although interleukin 17 (IL-17) has some roles in renal transplantation, the influence of IL-17 gene single-nucleotide polymorphisms (SNPs) on renal transplantation has not been studied.

Methods: The associations of 5 IL-17F gene SNPs (-1507G/A, 6329G/A, 7384A/G, 7470G/A, and 7489A/G) with renal transplantation outcome were analyzed. Polymerase chain reaction with sequence-specific primers (for -1507G/A and 6329G/A) and direct sequencing (for 7384A/G, 7470G/A, and 7489A/G) were performed on 282 renal transplantation recipients and 210 healthy controls.

Results: IL-17F SNPs were not associated with acute rejection. Recipients with G allele on 7489A/G showed lower graft survival than recipients without G allele (P = .04). In multivariate analysis, G allele on 7489A/G was an independent risk factor for graft failure (odds ratio = 2.77, P = .03).

Conclusion: IL-17F gene SNP 7489A/G was associated with renal graft failure. Further studies are needed in larger number of patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Case-Control Studies
  • Cytokines / metabolism
  • Female
  • Gene Frequency
  • Genotype
  • Graft Rejection
  • Graft Survival
  • Histocompatibility Testing
  • Humans
  • Inflammation
  • Interleukin-17 / genetics*
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Male
  • Multivariate Analysis
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Republic of Korea
  • Risk Factors
  • Treatment Outcome

Substances

  • Cytokines
  • Interleukin-17