Disease-related intestinal transplant in adults: results from a single center

Transplant Proc. 2014 Jan-Feb;46(1):245-8. doi: 10.1016/j.transproceed.2013.08.110.

Abstract

Intestinal transplantation is gaining worldwide acceptance as the main option for patients with irreversible intestinal failure and complicated total parenteral nutrition course. In adults, the main cause is still represented by short bowel syndrome, but tumors (Gardner syndrome) and dismotility disorders (chronic intestinal pseudo-obstruction [CIPO]) have been treated increasingly by this kind of transplantation procedure. We reviewed our series from the disease point of view: although SBS confirmed results achieved in previous years, CIPO is nowadays demonstrating an excellent outcome similar to other transplantation series. Our results showed indeed that recipients affected by Gardner syndrome must be carefully selected before the disease is to advanced to take advantage of the transplantation procedure.

MeSH terms

  • Adult
  • Age Factors
  • Alemtuzumab
  • Antibodies, Monoclonal, Humanized / administration & dosage
  • Antilymphocyte Serum / administration & dosage
  • Daclizumab
  • Female
  • Gardner Syndrome / surgery
  • Humans
  • Immunoglobulin G / administration & dosage
  • Immunosuppressive Agents / therapeutic use
  • Intestinal Diseases / surgery
  • Intestinal Pseudo-Obstruction / surgery
  • Intestines / physiopathology
  • Intestines / transplantation*
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Parenteral Nutrition, Total
  • Proportional Hazards Models
  • Short Bowel Syndrome / surgery
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal, Humanized
  • Antilymphocyte Serum
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Alemtuzumab
  • Daclizumab
  • thymoglobulin