Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation

Åsa Stenberg; Anna Karlsson; Elisabeth Feuk-Lagerstedt; Karin Christenson; Johan Bylund; Anna Oldenborg; Liselotte Vesterlund; Takashi Matozaki; Janove Sehlin; Per-Arne Oldenborg

doi:10.1159/000357820

Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation

J Innate Immun. 2014;6(4):553-60. doi: 10.1159/000357820. Epub 2014 Feb 7.

Authors

Åsa Stenberg¹, Anna Karlsson, Elisabeth Feuk-Lagerstedt, Karin Christenson, Johan Bylund, Anna Oldenborg, Liselotte Vesterlund, Takashi Matozaki, Janove Sehlin, Per-Arne Oldenborg

Affiliation

¹ Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.

Abstract

Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, Differentiation / genetics
Antigens, Differentiation / immunology
Antigens, Differentiation / metabolism
Cell Degranulation / genetics
Cell Membrane / metabolism*
Cells, Cultured
Feedback, Physiological
Gene Expression Regulation / immunology
Humans
Inflammation / genetics
Neutrophils / immunology*
Protein Transport
Receptors, Immunologic / genetics
Receptors, Immunologic / immunology
Receptors, Immunologic / metabolism
Secretory Vesicles / metabolism*

Substances

Antigens, Differentiation
Receptors, Immunologic
SIRPA protein, human