Can we build an efficient response to the prescription drug abuse epidemic? Assessing the cost effectiveness of universal prevention in the PROSPER trial

Prev Med. 2014 May:62:71-7. doi: 10.1016/j.ypmed.2014.01.029. Epub 2014 Feb 9.

Abstract

Purpose: Prescription drug abuse has reached epidemic proportions. Nonmedical prescription opioid use carries increasingly high costs. Despite the need to cultivate efforts that are both effective and fiscally responsible, the cost-effectiveness of universal evidence-based-preventive-interventions (EBPIs) is rarely evaluated. This study explores the performance of these programs to reduce nonmedical prescription opioid use.

Methods: Sixth graders from twenty-eight rural public school districts in Iowa and Pennsylvania were blocked by size and geographic location and then randomly assigned to experimental or control conditions (2002-2010). Within the intervention communities, prevention teams selected a universal family and school program from a menu of EBPIs. All families were offered a family-based program in the 6th grade and received one of three school-based programs in 7th-grade. The effectiveness and cost-effectiveness of each school program by itself and with an additional family-based program were assessed using propensity and marginal structural models.

Results: This work demonstrates that universal school-based EBPIs can efficiently reduce nonmedical prescription opioid use. Further, findings illustrate that family-based programs may be used to enhance the cost-effectiveness of school-based programs.

Conclusions: Universal EBPIs can effectively and efficiently reduce nonmedical prescription opioid use. These programs should be further considered when developing comprehensive responses to this growing national crisis.

Keywords: Cost-effectiveness; Nonmedical prescription drug use; Prevention economics; Substance abuse; Universal prevention.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Cost-Benefit Analysis
  • Evidence-Based Practice
  • Family / psychology*
  • Family Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Iowa
  • Male
  • Opioid-Related Disorders / epidemiology
  • Opioid-Related Disorders / prevention & control*
  • Outcome Assessment, Health Care
  • Pennsylvania
  • Program Evaluation*
  • Rural Population
  • Schools
  • Students / psychology*
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / prevention & control*
  • Time Factors
  • Treatment Outcome