Abstract
We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Coinfection / immunology*
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Coinfection / virology
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Disease Models, Animal
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Hepacivirus / growth & development
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Hepacivirus / immunology
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Hepacivirus / physiology*
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Hepatitis B / virology*
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Hepatitis B virus / growth & development
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Hepatitis B virus / immunology
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Hepatitis B virus / physiology*
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Hepatitis C, Chronic / immunology*
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Hepatocytes / virology
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Interferon Type I / biosynthesis
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Interferon Type I / immunology*
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Liver / virology
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Pan troglodytes
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Virus Replication*