Abstract
We have previously described two synthetic models gathering a simplified model of the complexing part of Bleomycin (Blm) and the intercalating moiety of m-AMSA. These molecules, namely AGGA and AGAMGA, do not seem able to cleave DNA as Blm does. The present work is devoted to the study of a new derivative, AGAGLU, which includes in its structure a judiciously chosen connector between the two parts of the molecule. This compound, the chelating and DNA-binding properties of which are described here, has been shown to induce single-strand breakage of duplex DNA in a high level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoacridines / chemical synthesis
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Aminoacridines / pharmacology*
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Amsacrine / pharmacology*
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Animals
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Bleomycin / pharmacology*
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Cattle
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Chelating Agents / pharmacology
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Circular Dichroism
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Copper
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DNA Damage*
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DNA-Binding Proteins / pharmacology*
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Drug Interactions
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Electron Spin Resonance Spectroscopy
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Free Radicals
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Glucosamine / analogs & derivatives*
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Glucosamine / chemical synthesis
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Glucosamine / pharmacology
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Spectrometry, Fluorescence
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Thymus Gland
Substances
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Aminoacridines
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Chelating Agents
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DNA-Binding Proteins
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Free Radicals
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Amsacrine
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Bleomycin
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(((amino-2-ethyl)-2-aminomethyl)-2-pyridine-6-carboxylhistidyl-gamma-(2-amino-2-deoxyglucosyl)glutamylglycylamino)-4-phenyl-1-aminoacridine
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Copper
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Glucosamine