The c-fos proto-oncogene in murine 3LL carcinoma clones controls the expression of MHC genes

Oncogene. 1988 Feb;2(2):119-27.

Abstract

The c-fos proto-oncogene and H-2K class I major histocompatibility antigens are differentially expressed in low-metastatic Lewis lung carcinoma clones, but not in high-metastatic clones. Interferons induce mRNA expression of fos and H-2 in non-expressor cells and elevate mRNA steady state levels of expressor cells. Transfection of non-expressor cells by v-fos or c-fos genes induces the transcription of H-2K mRNA and elevates the levels of H-2 proteins, but not of other gene products. These results, correlated with observations in other cell systems, suggest that the c-fos proto-oncogene controls the expression of MHC genes coding for class 1 antigens.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actins / genetics
  • Animals
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Gene Expression Regulation
  • Genes, MHC Class I*
  • H-2 Antigens / genetics*
  • Interferons / pharmacology
  • Methylation
  • Mice
  • Neoplasm Metastasis
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • Transcription, Genetic

Substances

  • Actins
  • H-2 Antigens
  • Proto-Oncogene Proteins
  • Interferons