An ionic liquid tolerant cellulase derived from chemically polluted microhabitats and its application in in situ saccharification of rice straw

Bioresour Technol. 2014 Apr:157:166-73. doi: 10.1016/j.biortech.2014.01.102. Epub 2014 Feb 4.

Abstract

A cellulase-producing fungus was isolated from chemically polluted microhabitats by [Amim][Cl] enrichment and identified as Aspergillus fumigatus. The maximum activity of the cellulase in 30% (v/v) ionic liquids (ILs) was detected in [Emim][DMP], [Amim][Cl] and [Emim][MA] as 127%, 111% and 109%, respectively, of its activity in buffer, suggesting its superior performance in high concentration ILs. Strikingly, although its initial activity varied in each IL, its half-life was longer in most ILs than in buffer, evidence of a high conformational stability of the enzyme that is essential for maintaining the remaining activity in relevant media. It noteworthy that 1-3M NaCl can activate the cellulase somewhat. More gratifyingly, a compatible IL-cellulase system based on the cellulase was developed, and its use significantly improved the saccharification rate of rice straw from 53% to 88% versus the control, demonstrating its potential for efficient transformation of lignocellulose to glucose in a single-step process.

Keywords: Cellulase; Ionic liquids; Lignocellulose; Saccharification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus fumigatus / enzymology
  • Carbohydrate Metabolism / drug effects*
  • Cellulase / metabolism*
  • Ecosystem*
  • Environmental Pollution*
  • Enzyme Stability / drug effects
  • Half-Life
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Ionic Liquids / pharmacology*
  • Oryza / chemistry*
  • Sodium Chloride / pharmacology
  • Temperature
  • Time Factors
  • Waste Products*

Substances

  • Ionic Liquids
  • Waste Products
  • Sodium Chloride
  • Cellulase