Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation

Adv Mater. 2014 May 28;26(20):3253-7. doi: 10.1002/adma.201304995. Epub 2014 Feb 18.

Abstract

A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.

Keywords: biomaterials; odontogenesis; poly(N-isopropylacrylamide); scaffold engineering; thermoresponsive.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acrylic Resins / chemistry*
  • Animals
  • Biocompatible Materials / chemistry
  • Biomimetic Materials / chemistry*
  • Bone Morphogenetic Protein 4 / metabolism
  • Cell Differentiation / physiology*
  • Hydrogels / chemistry
  • Kidney / physiology
  • Kidney / surgery
  • MSX1 Transcription Factor / metabolism
  • Mesenchymal Stem Cells / physiology*
  • Mice
  • Oligopeptides / chemistry
  • PAX9 Transcription Factor
  • Paired Box Transcription Factors / metabolism
  • Porosity
  • Temperature*
  • Tissue Scaffolds / chemistry*
  • Tooth / physiology

Substances

  • Acrylic Resins
  • Biocompatible Materials
  • Bmp4 protein, mouse
  • Bone Morphogenetic Protein 4
  • Hydrogels
  • MSX1 Transcription Factor
  • Msx1 protein, mouse
  • Oligopeptides
  • PAX9 Transcription Factor
  • Paired Box Transcription Factors
  • Pax9 protein, mouse
  • poly-N-isopropylacrylamide
  • glycyl-arginyl-glycyl-aspartyl-serine