Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity

J Virol. 2014 May;88(9):5165-70. doi: 10.1128/JVI.03765-13. Epub 2014 Feb 19.

Abstract

Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Neutralizing / immunology
  • Antibody Specificity*
  • Female
  • HIV Antibodies / immunology*
  • HIV-1 / immunology*
  • HIV-1 / isolation & purification
  • Immunoglobulin G / immunology
  • env Gene Products, Human Immunodeficiency Virus / immunology*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • HIV Antibodies
  • Immunoglobulin G
  • env Gene Products, Human Immunodeficiency Virus