Discrimination of the determinant specificity of two competitive Semliki Forest virus neutralizing monoclonal antibodies by anti-idiotypic antibodies

T A Oosterlaken; C A Kraaijeveld; A Snijders; M Harmsen; B J Benaissa-Trouw; H Snippe

doi:10.1007/BF01310913

Discrimination of the determinant specificity of two competitive Semliki Forest virus neutralizing monoclonal antibodies by anti-idiotypic antibodies

Arch Virol. 1988;100(1-2):115-20. doi: 10.1007/BF01310913.

Authors

T A Oosterlaken¹, C A Kraaijeveld, A Snijders, M Harmsen, B J Benaissa-Trouw, H Snippe

Affiliation

¹ Laboratorium voor Microbiologie, Rijksuniversiteit Utrecht, The Netherlands.

PMID: 2455492
DOI: 10.1007/BF01310913

Abstract

The two highly competitive, monoclonal antibodies (MAs), UM 5.1 and UM 8.1, recognize on the E2 glycoprotein of Semliki Forest virus different determinants as indicated by the absence of cross-reactive anti-idiotypic antibodies in rabbit immune sera induced against these highly neutralizing MAs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Anti-Idiotypic
Antibodies, Monoclonal*
Antibody Specificity
Binding, Competitive
Epitopes / analysis*
Immunoglobulin Idiotypes / immunology*
L Cells
Mice
Neutralization Tests
Semliki forest virus / immunology*
Viral Proteins / immunology*
Virus Cultivation

Substances

Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Epitopes
Immunoglobulin Idiotypes
Viral Proteins