Long-term survival after 66 hours of anhepatic time with no neurological deficit

Ann Transplant. 2014 Feb 21:19:93-5. doi: 10.12659/AOT.889604.

Abstract

Background: Intractable intraoperative hemorrhage is a rare complication of liver transplantation. Rescue hepatectomy with portocaval shunting can be used as a bridging procedure until a new organ donor becomes available. During the anhepatic period, however, there is a substantial risk of developing end-organ damage, the brain being particularly susceptible to insult.

Case report: A 66-year-old male underwent liver transplantation due to non-alcoholic steatotic hepatitis and hepatocellular carcinoma. The transplantation was complicated by perioperative intractable bleeding. Despite attempts to control the bleeding, the patient became hemodynamically unstable and a rescue hepatectomy with portocaval shunting was performed. The patient remained anhepatic for 66 hours in an intensive care unit until a second donor organ was found. He made a good recovery and had no neurological deficit.

Conclusions: Rescue hepatectomy with portocaval shunting is a viable short-term solution until a suitable donor organ is found. During this period, inotrope infusion and continuous veno-venous hemofiltration within an intensive care unit setting can be used as supportive measures. Nevertheless, a prolonged anhepatic time increases the risk of multiple organ failure and should be kept to a minimum due to metabolic disturbance and the build-up of toxic metabolites.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Blood Loss, Surgical*
  • Carcinoma, Hepatocellular / surgery*
  • Female
  • Hepatectomy*
  • Humans
  • Liver Neoplasms / surgery*
  • Liver Transplantation / adverse effects*
  • Male
  • Portasystemic Shunt, Surgical*
  • Survivors
  • Time Factors
  • Tissue Donors