Genetic analysis of adenosine deaminase expression in adult T-cell leukemia

Am J Hematol. 1988 Jun;28(2):119-21. doi: 10.1002/ajh.2830280212.

Abstract

We investigated the genetic basis for the increased adenosine deaminase (ADA) expression in adult T-cell leukemia (ATL). We found a correlation between the levels of ADA-specific mRNA and ADA immunoreactive protein in ATL. Southern blot analysis revealed no gene amplification or rearrangement of the ADA gene. These findings indicate that increased ADA expression in ATL cells reflects increased transcriptional activity for the ADA gene or increased stability of ADA mRNA.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adenosine Deaminase / metabolism*
  • Genetic Techniques
  • Humans
  • Leukemia / enzymology*
  • Leukemia / metabolism
  • Leukemia / pathology
  • Leukocytes, Mononuclear / enzymology
  • Male
  • Middle Aged
  • Nucleoside Deaminases / metabolism*
  • RNA / analysis
  • RNA, Messenger / analysis
  • T-Lymphocytes

Substances

  • RNA, Messenger
  • RNA
  • Nucleoside Deaminases
  • Adenosine Deaminase