Cytogenetically cryptic and FISH-negative PML/RARA rearrangement in acute promyelocytic leukemia detected only by PCR: an exceedingly rare phenomenon

Cancer Genet. 2014 Jan-Feb;207(1-2):48-9. doi: 10.1016/j.cancergen.2014.01.001. Epub 2014 Jan 16.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adolescent
  • Chromosomes, Human, Pair 15
  • Chromosomes, Human, Pair 17
  • Diagnosis, Differential
  • Disseminated Intravascular Coagulation / diagnosis
  • Gene Rearrangement
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / therapy
  • Leukemia, Promyelocytic, Acute / diagnosis*
  • Leukemia, Promyelocytic, Acute / genetics*
  • Leukemia, Promyelocytic, Acute / therapy
  • Leukocytosis / diagnosis
  • Male
  • Oncogene Proteins, Fusion / genetics*
  • Prognosis
  • Real-Time Polymerase Chain Reaction
  • Translocation, Genetic*

Substances

  • Oncogene Proteins, Fusion
  • promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein