Abstract
Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the toxic effects of some of these reactive molecules. However, thiol-based switches are common in protein sensors of antioxidant cascades, in both prokaryotic and eukaryotic organisms. We will describe here three redox sensors, the transcription factors OxyR, Yap1 and Pap1, which respond by disulfide bond formation to hydrogen peroxide stress, focusing specially on the differences among the three peroxide-sensing mechanisms.
Keywords:
Cys oxidation; H2O2 sensor; OxyR; Pap1; S. pombe; Yap1.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Basic-Leucine Zipper Transcription Factors / metabolism*
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Cysteine / metabolism*
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Cystine / metabolism
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Escherichia coli / genetics
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Escherichia coli / metabolism*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Gene Expression Regulation, Bacterial*
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Gene Expression Regulation, Fungal*
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Glutathione Peroxidase / metabolism
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Hydrogen Peroxide / metabolism*
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Oxidation-Reduction
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Oxidative Stress
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Pancreatitis-Associated Proteins
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Peroxiredoxins / metabolism
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Reactive Nitrogen Species / metabolism*
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Reactive Oxygen Species / metabolism*
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Repressor Proteins / metabolism
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
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Schizosaccharomyces / genetics
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Schizosaccharomyces / metabolism*
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Schizosaccharomyces pombe Proteins / genetics
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Schizosaccharomyces pombe Proteins / metabolism*
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Transcription Factors / metabolism
Substances
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Basic-Leucine Zipper Transcription Factors
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Escherichia coli Proteins
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Pancreatitis-Associated Proteins
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Pap1 protein, S pombe
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REG3A protein, human
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Reactive Nitrogen Species
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Reactive Oxygen Species
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Repressor Proteins
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Saccharomyces cerevisiae Proteins
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Schizosaccharomyces pombe Proteins
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Tpx1 protein, S pombe
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Transcription Factors
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YAP1 protein, S cerevisiae
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oxyR protein, E coli
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Cystine
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Hydrogen Peroxide
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Peroxiredoxins
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Glutathione Peroxidase
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HYR1 protein, S cerevisiae
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Cysteine