Abstract
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amaryllidaceae Alkaloids / administration & dosage*
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Amaryllidaceae Alkaloids / chemical synthesis*
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Amaryllidaceae Alkaloids / chemistry
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Cell Proliferation / drug effects
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HCT116 Cells
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Humans
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Liliaceae / chemistry
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Phenanthridines / administration & dosage*
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Phenanthridines / chemical synthesis*
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Phenanthridines / chemistry
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Plant Extracts / chemistry
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Structure-Activity Relationship
Substances
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Amaryllidaceae Alkaloids
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Antineoplastic Agents
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Phenanthridines
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Plant Extracts
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lycorine