Abstract
A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemical synthesis
-
Anti-HIV Agents / chemistry
-
Anti-HIV Agents / pharmacology*
-
Binding Sites / drug effects
-
Cyclodextrins / chemistry*
-
Dendritic Cells / drug effects
-
Glycoconjugates / chemical synthesis
-
Glycoconjugates / chemistry
-
Glycoconjugates / pharmacology*
-
HIV / drug effects*
-
HIV Envelope Protein gp120 / antagonists & inhibitors*
-
Humans
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Polymerization
-
Structure-Activity Relationship
Substances
-
Anti-HIV Agents
-
Cyclodextrins
-
Glycoconjugates
-
HIV Envelope Protein gp120