[From prion diseases to Alzheimer's disease: a common therapeutic target, PDK1]

Med Sci (Paris). 2014 Feb;30(2):139-41. doi: 10.1051/medsci/20143002008. Epub 2014 Feb 24.

[Article in French]

Authors

Mathéa Pietri¹, Aurélie Alleaume-Butaux¹, Jean-Marie Launay², Odile Kellermann¹, Benoit Schneider¹

Affiliations

¹ Université Paris Descartes, Inserm UMR-S 747, Sorbonne Paris Cité, 45, rue des Saints-Pères, 75006 Paris, France.
² AP-HP, service de biochimie, Inserm UMR-S 942, 45, rue des Saints-Pères, 75006 Paris, France - Pharma research department, Hoffmann La Roche, Bâle, Suisse.

PMID: 24572109
DOI: 10.1051/medsci/20143002008

No abstract available

Publication types

News

MeSH terms

ADAM Proteins / metabolism
ADAM17 Protein
Alzheimer Disease / enzymology*
Enzyme Inhibitors / therapeutic use
Humans
Prion Diseases / enzymology*
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / physiology*
Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Substances

Enzyme Inhibitors
PDK1 protein, human
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Protein Serine-Threonine Kinases
ADAM Proteins
ADAM17 Protein