An unusual case of a combination of trigeminal and intermediate nerve neuralgia is presented, caused by vascular compression of both of the nerve roots by different vessels. Because the neuralgia of the intermediate nerve could be cured by a vascular decompression operation, it is suggested to include it among the hyperactive dysfunction syndromes of cranial nerves caused by vascular compression at the root entry zone of the nerves. Therefore also for treatment of this neuralgia the non-destructive vascular decompression operation should be taken into consideration.