[Osteoconductive behaviour of beta-tricalcium phosphate ceramics in osteoporotic, metaphyseal bone defects of the distal radius]

Handchir Mikrochir Plast Chir. 2014 Feb;46(1):12-7. doi: 10.1055/s-0034-1366999. Epub 2014 Feb 26.
[Article in German]

Abstract

Background: Surgical treatment of osteoporotic distal radius fractures with locking plates does not completely prevent loss of reduction. Additional bone deficit stabilisation with the use of bone substitute materials is receiving increased attention. Most knowledge on the in vivo behavior of bone substitutes originates from a small number of animal models after its implantation in young, good vascularized bone.

Purpose: This paper investigates the osteoconductivity, resorption and biocompatibility of beta-tricalcium phosphate as a temporary bone replacement in osteoporotic type distal radius fractures.

Patients and methods: 15 bone samples taken from the augmented area of the distal radius of elderly people during metal removal were examined.

Results: The material was found to be osteoconductive, good degradable, and biocompatible. Degrading process and remodelling to woven bone seem to require more time than in available comparative bioassays.

Conclusions: The material is suitable for temporary replacement of lost, distal radius bone from the histological point of view.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Regeneration / physiology*
  • Bone Remodeling / physiology
  • Bone Substitutes*
  • Calcium Phosphates / therapeutic use*
  • Female
  • Follow-Up Studies
  • Fracture Fixation, Internal / methods*
  • Fracture Healing / physiology
  • Humans
  • Male
  • Materials Testing
  • Middle Aged
  • Osseointegration / physiology
  • Osteoporotic Fractures / pathology
  • Osteoporotic Fractures / surgery*
  • Radius / pathology
  • Radius / surgery
  • Radius Fractures / pathology
  • Radius Fractures / surgery*
  • Switzerland
  • Wrist Injuries / pathology
  • Wrist Injuries / surgery*

Substances

  • Bone Substitutes
  • Calcium Phosphates
  • beta-tricalcium phosphate