Manipulating nuclear architecture

Curr Opin Genet Dev. 2014 Apr:25:1-7. doi: 10.1016/j.gde.2013.10.014. Epub 2013 Dec 12.

Abstract

The eukaryotic genome is highly organized in the nucleus. Genes can be localized to specific nuclear compartments in a manner reflecting their activity. A plethora of recent reports has described multiple levels of chromosomal folding that can be related to gene-specific expression states. Here we discuss studies designed to probe the causal impact of genome organization on gene expression. The picture that emerges is that of a reciprocal relationship in which nuclear organization is not only shaped by gene expression states but also directly influences them.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics*
  • Chromatin / chemistry
  • Chromatin / genetics*
  • Gene Expression
  • Genome
  • Humans

Substances

  • Chromatin