Inhibition of folate-dependent enzymes by 7-OH-methotrexate

Biochem Pharmacol. 1988 Sep 15;37(18):3531-4. doi: 10.1016/0006-2952(88)90709-5.

Authors

P W Sholar¹, J Baram, R Seither, C J Allegra

Affiliation

¹ Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892.

PMID: 2458733
DOI: 10.1016/0006-2952(88)90709-5

No abstract available

MeSH terms

Acyltransferases / antagonists & inhibitors*
Folic Acid Antagonists / pharmacology*
Humans
Hydroxymethyl and Formyl Transferases*
Methotrexate / analogs & derivatives*
Methotrexate / pharmacology
Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Polyglutamic Acid / analogs & derivatives
Polyglutamic Acid / pharmacology
Thymidylate Synthase / antagonists & inhibitors*

Substances

Folic Acid Antagonists
Polyglutamic Acid
methotrexate polyglutamate
Thymidylate Synthase
Hydroxymethyl and Formyl Transferases
Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Acyltransferases
7-hydroxymethotrexate
Methotrexate