Abstract
Twelve new A,D-seco-limonoids, clauemargines A-L (1-12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8-10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values<10 μM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Clausena / chemistry*
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Crystallography, X-Ray
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Hep G2 Cells
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Humans
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Inhibitory Concentration 50
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Limonins / chemistry
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Limonins / isolation & purification*
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Limonins / pharmacology
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Meliaceae / chemistry*
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Mice
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Molecular Conformation
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
Substances
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Drugs, Chinese Herbal
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Limonins
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Lipopolysaccharides
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Nitric Oxide