Feasibility of low-dose contrast medium high pitch CT angiography for the combined evaluation of coronary, head and neck arteries

PLoS One. 2014 Mar 3;9(3):e90268. doi: 10.1371/journal.pone.0090268. eCollection 2014.

Abstract

Purpose: To evaluate the image quality and radiation dose of combined heart, head, and neck CT angiography (CTA) using prospectively electrocardiography (ECG)-triggered high-pitch spiral scan protocol, compared with single coronary CTA.

Materials and methods: 151 consecutive patients were prospectively included and randomly divided into three groups. Group 1 (n = 47) underwent combined heart, neck, and head CTA using prospectively ECG-triggered high-pitch spiral (Flash) scan protocol with a single-phase intravenous injection of iodinated contrast and saline flush; Group 2 (n = 51) underwent single coronary CTA with Flash scan protocol; and Group 3 (n = 53) underwent single coronary CTA with prospective sequence scan protocol. All patients were examined on a dual source CT (Definition FLASH). The image quality was determined for each CT study.

Results: Patients of scanning protocol Group 1, 2, and 3 showed no significant differences in age, sex, heart rates, and BMI. Evaluation of coronary artery image quality showed comparable results in the three scanning protocol groups on a per patient-based analysis. In group 1, image quality was found to be sufficient to be diagnostic in all arterial segments of carotid arteries. The mean dose-length product (DLP) for group 1 was 256.3±24.5 mGy×cm and was significantly higher in comparison with group 2 (93.4±19.9 mGy×cm; p < 0.001). However, there was no significant difference of DLP between group 1 and group 3 (254.1±69.9 mGy×cm).

Conclusions: The combined heart, neck, and head arteries scan using prospectively electrocardiography (ECG)-triggered high-pitch spiral scan protocol in 1 single examination resulted in an excellent opacification of the aorta, the carotid arteries, and the coronary arteries and provided a good image quality with low radiation dose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiography / methods*
  • Contrast Media / administration & dosage*
  • Coronary Vessels / diagnostic imaging*
  • Dose-Response Relationship, Drug
  • Feasibility Studies
  • Head / blood supply*
  • Humans
  • Neck / blood supply*
  • Tomography, X-Ray Computed

Substances

  • Contrast Media

Grants and funding

This work was supported by the National Natural Science Fundation of China (Grant number: 81000629) and Beijing Nova of Science and Technology (Grant number: Z121107002512072). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.