Abstract
A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiaris / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cardenolides / chemistry
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Cardenolides / isolation & purification*
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Cardenolides / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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HeLa Cells
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Hep G2 Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Extracts / chemistry
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Seeds / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Cardenolides
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Drugs, Chinese Herbal
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Plant Extracts
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periplogulcoside