Copper-catalyzed oxyazidation of unactivated alkenes: a facile synthesis of isoxazolines featuring an azido substituent

Org Lett. 2014 Mar 21;16(6):1562-5. doi: 10.1021/ol403687k. Epub 2014 Mar 5.

Abstract

A novel and efficient Cu(OAc)2-catalyzed oxyazidation of unactivated alkenes was developed. The reactions are easy to conduct, occur under mild conditions, and form azido-substituted isoxazolines in good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Azides / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkenes
  • Azides
  • Isoxazoles
  • Copper