Olfactory ensheathing cells seeded muscle-stuffed vein as nerve conduit for peripheral nerve repair: a nerve conduction study

J Biosci Bioeng. 2014 Aug;118(2):231-4. doi: 10.1016/j.jbiosc.2014.02.002. Epub 2014 Mar 2.

Abstract

We evaluated bridging of 15 mm nerve gap in rat sciatic nerve injury model with muscle-stuffed vein seeded with olfactory ensheathing cells as a substitute for nerve autograft. Neurophysiological recovery, as assessed by electrophysiological analysis was faster in the constructed biological nerve conduit compared to that of autograft.

Keywords: Compound motor action potential; Latency; Muscle-stuffed vein; Nerve conduction study; Olfactory ensheathing cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Muscle, Skeletal / pathology
  • Nerve Regeneration*
  • Neural Conduction
  • Olfactory Nerve / pathology
  • Peripheral Nerve Injuries / therapy
  • Rats, Sprague-Dawley
  • Regenerative Medicine
  • Sciatic Nerve / pathology
  • Sciatic Nerve / physiopathology*
  • Tissue Engineering*
  • Veins / pathology