Abstract
One novel p-terphenyl compound, polyozellic acid (1), and its acetone adduct (3), along with a known p-terphenyl compound, thelephoric acid (2), were isolated from the mushroom Polyozellus multiplex. Their molecular structures were determined by spectroscopic analysis, X-ray crystallographic analysis, and chemical modification. In some assays related to angiogenesis, compounds 1 and 2 in particular showed inhibitory effects on proliferation, tubule formation, and invasion of human umbilical vein endothelial cells. The quinone moiety within these molecules possibly contributes to their antiangiogenesis activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / chemistry*
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Angiogenesis Inhibitors* / chemistry
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Angiogenesis Inhibitors* / isolation & purification
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Angiogenesis Inhibitors* / pharmacology
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Crystallography, X-Ray
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Fruiting Bodies, Fungal / chemistry
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Human Umbilical Vein Endothelial Cells / drug effects
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Humans
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Inhibitory Concentration 50
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Japan
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Molecular Conformation
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Molecular Structure
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Terphenyl Compounds* / chemistry
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Terphenyl Compounds* / isolation & purification
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Terphenyl Compounds* / pharmacology
Substances
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Angiogenesis Inhibitors
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Terphenyl Compounds
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polyozellic acid
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thelephoric acid