Olfactory sulcus morphology in established bipolar affective disorder

Tsutomu Takahashi; Gin S Malhi; Yumiko Nakamura; Michio Suzuki; Christos Pantelis

doi:10.1016/j.pscychresns.2014.02.005

Olfactory sulcus morphology in established bipolar affective disorder

Psychiatry Res. 2014 Apr 30;222(1-2):114-7. doi: 10.1016/j.pscychresns.2014.02.005. Epub 2014 Feb 18.

Authors

Tsutomu Takahashi¹, Gin S Malhi², Yumiko Nakamura³, Michio Suzuki³, Christos Pantelis⁴

Affiliations

¹ Department of Neuropsychiatry, University of Toyama, Toyama, Japan. Electronic address: [email protected].
² Discipline of Psychological Medicine, Northern Clinical School, University of Sydney, Sydney, NSW, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, Sydney, NSW, Australia.
³ Department of Neuropsychiatry, University of Toyama, Toyama, Japan.
⁴ Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne, VIC, Australia.

PMID: 24602518
DOI: 10.1016/j.pscychresns.2014.02.005

Abstract

This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with bipolar I disorder and 24 matched controls. Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder.

Keywords: Bipolar disorder; Magnetic resonance imaging; Neurodevelopment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bipolar Disorder / pathology*
Female
Frontal Lobe / pathology*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Olfactory Pathways / pathology*
Organ Size