Abstract
Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Drug Carriers / chemistry*
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Drug Liberation*
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Gastrointestinal Tract / enzymology
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Hydrogen-Ion Concentration
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Models, Molecular
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Molecular Conformation
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Nanoparticles / chemistry*
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Porosity
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Prodrugs / chemistry
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Prodrugs / metabolism
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Silicon Dioxide / chemistry*
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Sulfasalazine / chemistry*
Substances
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Drug Carriers
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Prodrugs
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Sulfasalazine
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Silicon Dioxide