Abstract
Supernatants from endotoxin-stimulated human leukemic cells and human recombinant interferon-beta 2 similarly enhance synthesis of alpha 1-antichymotrypsin and haptoglobin but suppress synthesis of albumin in cultured Hep G2 cells. Human recombinant tumor necrosis factor only slightly affects production of alpha 1-antichymotrypsin and albumin in a similar manner as leukocyte cytokines. In distinction, recombinant human interferon-gamma profoundly inhibits synthesis of alpha 1-antichymotrypsin, and especially of haptoglobin, but stimulates production of alpha 2-macroglobulin thus modulating the acute phase response of these cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute-Phase Proteins / biosynthesis*
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Albumins / biosynthesis
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Biological Factors / pharmacology
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Blood Proteins / biosynthesis
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Carcinoma, Hepatocellular / metabolism
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Cytokines
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Fibrinogen / biosynthesis
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Haptoglobins / biosynthesis
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Humans
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Interferon Type I / pharmacology
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Interferon-gamma / pharmacology*
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Liver Neoplasms
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Neoplasm Proteins / biosynthesis
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Recombinant Proteins
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Tumor Cells, Cultured
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Tumor Necrosis Factor-alpha / pharmacology
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alpha 1-Antichymotrypsin / biosynthesis
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alpha 1-Antitrypsin
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alpha-Macroglobulins / biosynthesis
Substances
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Acute-Phase Proteins
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Albumins
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Biological Factors
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Blood Proteins
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Cytokines
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Haptoglobins
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Interferon Type I
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Neoplasm Proteins
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Recombinant Proteins
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Tumor Necrosis Factor-alpha
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alpha 1-Antichymotrypsin
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alpha 1-Antitrypsin
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alpha-Macroglobulins
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Interferon-gamma
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Fibrinogen