Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation

Adv Mater. 2014 May 21;26(19):3003-8. doi: 10.1002/adma.201304880. Epub 2014 Mar 11.

Abstract

Cell and islet microencapsulation in synthetic hydrogels provides an immunoprotective and cell-supportive microenvironment. A microfluidic strategy for the genaration of biofunctionalized, synthetic microgel particles with precise control over particle size and molecular permeability for cell and protein delivery is presented. These engineered capsules support high cell viability and function of encapsulated human stem cells and islets.

Keywords: cell microencapsulation; hydrogels; microfluidics; pancreatic islets; synthetic microgel.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Survival / drug effects
  • Humans
  • Hydrogels / chemistry*
  • Islets of Langerhans / cytology*
  • Maleimides / chemistry
  • Mesenchymal Stem Cells / cytology*
  • Microfluidic Analytical Techniques / methods*
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*
  • Polymers / pharmacology

Substances

  • Hydrogels
  • Maleimides
  • Polymers
  • maleimide
  • Polyethylene Glycols