Mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde

Org Biomol Chem. 2014 Apr 28;12(16):2523-7. doi: 10.1039/c3ob42431f.

Abstract

A mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde has been developed, which provides a practical synthetic strategy for the synthesis of indole derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Alkynes / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Crystallography, X-Ray
  • Gold / chemistry*
  • Hydrogenation
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Models, Molecular
  • Molecular Structure

Substances

  • Aldehydes
  • Alkynes
  • Amines
  • Indoles
  • Gold