Epidemiology of snakebite and use of antivenom in Argentina

Trans R Soc Trop Med Hyg. 2014 May;108(5):269-76. doi: 10.1093/trstmh/tru038. Epub 2014 Mar 11.

Abstract

Background: The incidence and case fatality rate of snakebite in Argentina are poorly known.

Methods: The authors used questionnaires provided with antivenoms by the primary manufacturer of anti-venoms in Argentina.

Results: A total of 8083 completed questionnaires was collected between 1978 and 1998. The annual incidence of snakebite was 1.8 bites per 100,000 inhabitants, with a high geographical heterogeneity; in the northern provinces of the country, the incidence can exceed 150 snakebites per 100,000 people per year. Bothrops (pit viper) bites predominated, accounting for 96.6% (6720/6957) of envenomations, bites from Crotalus (rattlesnake) accounted for 2.8% (195/6957), and bites from Micrurus (coral snake) for 0.6% (42/6957). Most patients were young men, who were generally bitten during agricultural activities, i.e. while working in the fields. Most snakebites (78.9%, 5852/7419) were to the lower limb, including 58.3% (4322/7419) to the foot. The case fatality rate was <0.04% (3/8083). Most envenomations (90%, 7275/8083) were treated with specific antivenom during the first 4 h after the bite. The median dose of antivenom was two vials for viper bites (Bothrops and Crotalus) and three vials for Micrurus bites.

Conclusion: These preliminary results should enable manufacturers to increase the availability of appropriate antivenom and health authorities to improve the management of snakebites where they are most common.

Keywords: Antivenom; Argentina; Bothrops; Crotalus; Micrurus; Snakebite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antivenins / administration & dosage*
  • Argentina / epidemiology
  • Bothrops*
  • Crotalus*
  • Drug Administration Schedule
  • Elapidae*
  • Emergency Service, Hospital / standards*
  • Female
  • Humans
  • Male
  • Seasons
  • Snake Bites / drug therapy
  • Snake Bites / epidemiology*
  • Snake Bites / immunology
  • Surveys and Questionnaires
  • Treatment Outcome

Substances

  • Antivenins