SnapShot: talin and the modular nature of the integrin adhesome

Feng Ye; Frederic Lagarrigue; Mark H Ginsberg

doi:10.1016/j.cell.2014.02.048

SnapShot: talin and the modular nature of the integrin adhesome

Cell. 2014 Mar 13;156(6):1340-1340.e1. doi: 10.1016/j.cell.2014.02.048.

Authors

Feng Ye¹, Frederic Lagarrigue¹, Mark H Ginsberg¹

Affiliation

¹ Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Integrin αβ transmembrane heterodimers play central roles in metazoan development and physiology by mediating adhesion and by transmitting forces and biochemical signals across the plasma membrane. In this SnapShot, we present a simplified "modular" view of the integrin adhesome, centered on the talin-integrin interaction, and provide examples of how this view can help to unravel the adhesome's remarkable functional diversity and plasticity.

MeSH terms

Amino Acid Sequence
Animals
Cell Adhesion
Integrins / chemistry
Integrins / metabolism*
Molecular Sequence Data
Talin / chemistry
Talin / metabolism*

Substances

Integrins
Talin

Abstract

MeSH terms

Substances

Grants and funding