CrossTalk proposal: The preBotzinger complex is essential for the respiratory depression following systemic administration of opioid analgesics

J Physiol. 2014 Mar 15;592(6):1159-62. doi: 10.1113/jphysiol.2013.261974.
No abstract available

MeSH terms

  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects*
  • Animals
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / administration & dosage
  • Humans
  • Medulla Oblongata / drug effects*
  • Medulla Oblongata / physiopathology
  • Models, Neurological
  • Motor Neurons / drug effects
  • Motor Neurons / physiology
  • Receptors, Opioid, mu / agonists
  • Respiratory Center / drug effects
  • Respiratory Center / physiopathology
  • Respiratory Insufficiency / chemically induced*
  • Respiratory Insufficiency / physiopathology
  • Respiratory Insufficiency / prevention & control
  • Respiratory Rate / drug effects
  • Respiratory Rate / physiology

Substances

  • Analgesics, Opioid
  • Receptors, Opioid, mu
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-